Endocrine Abstracts

Fifty-three year old male presented to gastroenterologist with retrosternal pain and dysphagia. On gastroscopy a 2 cm soft sub-pedunculated polypoid mass in the lower oesophagus was identified and on biopsy it was confirmed as adenocarcinoma. CT scan confirmed the finding but additionally identified 20mm right adrenal “incidentaloma” with mild calcification and reassuring imaging characteristics, further supported by a low uptake on 18-FDG PET-CT. He underwent Ivor L...

Introduction: Vasculitis is a rare complication of anti-thyroid medications and is more common with propylthiouracil than carbimazole. Patients often have multisystem involvement although renal and dermatological manifestations are common. Although most cases resolve following withdrawal of the offending agent, not all do and rare instances of death have been reported in the literature. Immunosuppressive therapy can be used to improve organ function and prevent progression.</p...

A 29 year-old nursing student, was incidentally detected to have high serum calcium 3.43 mmol/l (2.2-2.6) whilst being treated for community acquired pneumonia. She had no symptoms of hypercalcaemia. Her uncle had been operated for primary hyperparathyroidism (PHPT) although only limited details were available. PTH of 28 pmol/l (1.6-7.2) confirmed the diagnosis of PHPT. She had vitamin D deficiency, normal liver and renal function. She was offered parathyroidectomy and preoper...

Background: Management of PHPT includes successful localization of parathyroid adenoma(s) by nuclear imaging and ultrasound scans allowing focused or minimally invasive surgery. Our aim was to assess the accuracy of parathyroid imaging in surgically-treated patients with primary hyperparathyroidism (PHPT) by correlating the imaging findings with surgical findings and cure of hyperparathyroidism. We also compared the surgical outcomes in patients with con...

Adrenal insufficiency is an uncommon endocrine condition with an incidence of 4 cases per million. Common non-iatrogenic causes include autoimmunity, infections and infiltrations. We describe a case of acute adrenal insufficiency secondary to an unusual cause.A 77-year old female was admitted under the surgeons with abdominal pain and pyrexia. Abdominal ultrasonography showed large stones within a thickened gallbladder and a pr...

Background: Management of PHPT includes successful localization of parathyroid adenoma(s) by nuclear imaging and ultrasound scans allowing focused or minimally invasive surgery. Our aim was to assess the accuracy of parathyroid imaging in surgically-treated patients with primary hyperparathyroidism (PHPT) by correlating the imaging findings with surgical findings and cure of hyperparathyroidism. We also compared the surgical outcomes in patients with con...

Adrenal insufficiency is an uncommon endocrine condition with an incidence of 4 cases per million. Common non-iatrogenic causes include autoimmunity, infections and infiltrations. We describe a case of acute adrenal insufficiency secondary to an unusual cause.A 77-year old female was admitted under the surgeons with abdominal pain and pyrexia. Abdominal ultrasonography showed large stones within a thickened gallbladder and a pr...

Background: Immune related adverse events (iRAEs) of the endocrine system are commonly recognised in Checkpoint Inhibitor (CTLA-4 and PD-1 inhibitors) Therapy. Clinically, endocrinopathies can present with symptoms of hormone deficiency, hormone excess or both (in the same or different glands).Aim: Audit of Incidence and Management (detection, investigation, referral and management) practices of Endocrinopathies due to Immunotherapy in Oncology departmen...

Background: We present a case of a 33 year old female with a background of Turner’s syndrome, adequately managed with growth hormone and oestrogen supplementation, Crohn’s disease, horse shoe kidney and subclinical hypothyroidismCase details: She presented to the emergency team with high-grade fever and right sided hemiplegia 10 days following Astra Zeneca COVID vaccination. Initial blood tests showed mildly raised CRP of 49, thrombocytopenia w...

A 53-year old male presented to his optician with blurring of vision on the right and was diagnosed to have branch retinal vein occlusion. Over the next 6 weeks he manifested further visual impairment, initially due to right central retinal venous occlusion (CRVO) and after another 3 months left CRVO. He received intravitreal Ranibizumab injections and timolol-dorzolamide eye drops in both eyes. Soon after this, he had a hospital admission for infected submandibular gland and ...